克罗米酚对男性高促性腺素性功能减退症有效

纽约（法新社健康版）1月底四日刊文：据发表在12月底年出版的《怀孕与不育》杂志的一项调查结果援引克罗米酮对部分低促性腺伦性机制减退的男性病患有利。来自布拉德福德肯塔基国立大学的该调查结果的第一编者Scott J. Whitten博士在给予路透通讯社报道时说：“原发性或诱导HH病患在给予侵害性更大和更为昂贵的外科手术（例如注射促性腺激伦类）前所顺利完成4个月底的克罗米酮在在外科手术是有利的。”Whitten博士和同事分析了克罗米酮对10名HH男性病患（HH是致使男性不育的少见考量）是否有效。调查结果指克罗米酮外科手术1年后，4名卡尔曼(氏)肉瘤病患中只有一名病患的胚胎分子量减小而全垂体机制减退症病患的胚胎缺乏症状均很难得到改善。相反，该调查结果援引3名成年确诊的原发性HH男性病患经过3个月底克罗米酮的外科手术胚胎分子量有了明显减小。目前所为止该组病患才有两名趋于稳定了后生。Whitten博士说：“除非对克罗米酮外科手术很难反应，我们不会因为副作用停止对病患可用该药剂。”最后编者总结说：“因为条件有限，对HH病患促性腺激伦类药剂和克罗米酮的随机分析难以顺利完成，然而利用多系列的严格选取规格对病患顺利完成分级可能帮助进一步可验证克罗米酮趋于稳定男性低后生的理论上。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色幻想

编辑： 张靖